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Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 12, p e0226973 (2019)
- Publication Year :
- 2019
-
Abstract
- Gene effects on osteoporosis have been studied separately and may have been masked by gene-gene and gene-environment interactions. We evaluated gene-gene and gene-physical activity interactions of the variants of tumor necrosis factor-α (TNF-α) and vitamin D receptor (VDR) genes on osteoporosis. A total of 472 elders were included. Seven variants (TNF-α: rs1799964, rs1800629, rs3093662; VDR: rs7975232, rs1544410, rs2239185, rs3782905) were genotyped. Bone mineral densities of the lumbar spine, femoral neck, and total hip were measured by dual-energy X-ray absorptiometry. Predictive models' ability to discriminate osteoporosis status was evaluated by areas under the receiver operating characteristics (AUROC) curve. After multivariable adjustment, significant interactions of TNF-α rs1800629 and VDR rs3782905 were observed on overall and lumbar spine osteoporosis. In elderly women, we found that those carrying the CG/CC genotype of VDR rs3782905 were significantly associated with increased odds of overall osteoporosis compared with those carrying the GG genotype of VDR rs3782905 among those carrying TNF-α rs1800629 GG genotype. The adjusted odds ratios (ORs) for VDR rs3782905 CG/CC genotype in elderly women carrying TNF-α rs1800629 AG/AA and GG genotypes were 0.1 (0.01, 0.98) and 3.54 (1.51, 8.30), respectively. We observed significant differences in AUROCs between the model with traditional covariates plus variants and their interaction term and the model with traditional covariates only (AUROCs: 0.77 and 0.81; p = 0.028). Although the sample size of this study may have been relatively small, our results suggest that the interaction of the CG/CC genotype of VDR rs3782905 with TNF-α rs1800629 GG genotype was associated with increased odds of overall and lumbar spine osteoporosis in elderly women.
- Subjects :
- 0301 basic medicine
Heredity
Bone density
Physiology
Osteoporosis
Organic chemistry
Pathology and Laboratory Medicine
Calcitriol receptor
0302 clinical medicine
Elderly
Polymorphism (computer science)
Bone Density
Immune Physiology
Genotype
Medicine and Health Sciences
Public and Occupational Health
Vitamin D
Connective Tissue Diseases
Immune Response
Aged, 80 and over
Innate Immune System
Multidisciplinary
Vitamins
Physical sciences
Chemistry
Genetic Mapping
medicine.anatomical_structure
Connective Tissue
Area Under Curve
Medicine
Cytokines
Female
Independent Living
Anatomy
Research Article
medicine.medical_specialty
Science
Immunology
Variant Genotypes
Polymorphism, Single Nucleotide
03 medical and health sciences
Chemical compounds
Signs and Symptoms
Gene interaction
Rheumatology
Diagnostic Medicine
Internal medicine
Organic compounds
medicine
Genetics
Humans
Bone
Femoral neck
Aged
Inflammation
business.industry
Tumor Necrosis Factor-alpha
Genetic Variation
Biology and Life Sciences
Epistasis, Genetic
Odds ratio
Physical Activity
Molecular Development
medicine.disease
030104 developmental biology
Endocrinology
Biological Tissue
ROC Curve
Age Groups
Immune System
People and Places
Receptors, Calcitriol
Population Groupings
business
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....92de0b837bacb8f324c5b71aa98ce79e