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Leucocontextins A–R, lanostane-type triterpenoids from Ganoderma leucocontextum
- Source :
- Fitoterapia. 109:91-98
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Eighteen new lanostane-type triterpenoids, namely leucocontextins A-R (1-18) were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures were established by 1D and 2D NMR data in conjunction with HRESIMS/HREIMS, X-ray single crystal diffraction analysis. Compound 18 exhibited weak cytotoxicity against K562 and MCF-7 cell lines with IC50 of 20-30 μM.
- Subjects :
- Pharmacology
Molecular Structure
010405 organic chemistry
Stereochemistry
Ganoderma
Ganoderma leucocontextum
General Medicine
01 natural sciences
Lanostane
Triterpenes
Single Crystal Diffraction
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry.chemical_compound
Triterpenoid
chemistry
Drug Discovery
MCF-7 Cells
Humans
Fruiting Bodies, Fungal
K562 Cells
Cytotoxicity
Two-dimensional nuclear magnetic resonance spectroscopy
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 109
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....9319cef534fe193a768b8be5dfcbb08c
- Full Text :
- https://doi.org/10.1016/j.fitote.2015.12.004