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Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis
Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis
- Source :
- Journal of gastroenterology. 29(2)
- Publication Year :
- 1994
-
Abstract
- Hepatic polyamines were assayed in 15 patients with liver diseases, 5 with fulminant hepatitis (FH); 3 with exacerbated liver cirrhosis (ELC); and 7 with liver cirrhosis (LC). Hepatic putrescine and N1-acetylspermidine, as percentages of total polyamines, were elevated and spermine was decreased in all 15 patients. The increase in hepatic N1-acetylspermidine levels appeared to be greater in patients with FH and ELC than in those with LC. These results suggest that the production of N1-acetylspermidine in human liver is closely associated with the induction of spermidine/spermine N1-acetyltransferase activity in liver diseases.
- Subjects :
- Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Spermidine
Spermine
Gastroenterology
Hepatitis
chemistry.chemical_compound
Surgical oncology
Acetyltransferases
Internal medicine
Putrescine
Medicine
Humans
Fulminant hepatitis
Aged
medicine.diagnostic_test
business.industry
Hepatology
Middle Aged
medicine.disease
chemistry
Liver
Hepatic Encephalopathy
Female
business
Liver function tests
Subjects
Details
- ISSN :
- 09441174
- Volume :
- 29
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....9337be1134385e24529f49b1bbcd11dc