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Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis

Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis

Authors :
Hitoshi Takagi
Takehiko Abe
Takeaki Nagamine
Hitomi Takahashi
Seiji Sakurai
Shigeru Matsuzaki
Jiro Takezawa
Hiroyuki Sugimoto
Source :
Journal of gastroenterology. 29(2)
Publication Year :
1994

Abstract

Hepatic polyamines were assayed in 15 patients with liver diseases, 5 with fulminant hepatitis (FH); 3 with exacerbated liver cirrhosis (ELC); and 7 with liver cirrhosis (LC). Hepatic putrescine and N1-acetylspermidine, as percentages of total polyamines, were elevated and spermine was decreased in all 15 patients. The increase in hepatic N1-acetylspermidine levels appeared to be greater in patients with FH and ELC than in those with LC. These results suggest that the production of N1-acetylspermidine in human liver is closely associated with the induction of spermidine/spermine N1-acetyltransferase activity in liver diseases.

Details

ISSN :
09441174
Volume :
29
Issue :
2
Database :
OpenAIRE
Journal :
Journal of gastroenterology
Accession number :
edsair.doi.dedup.....9337be1134385e24529f49b1bbcd11dc