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Cardiovascular and Renal Benefits of SGLT2 Inhibitors: A Narrative Review
- Source :
- International Journal of Endocrinology and Metabolism
- Publication Year :
- 2018
-
Abstract
- Context Most recently developed anti-hyperglycemic drugs have offered cardiovascular and renal benefits. In this narrative review, we discuss the cardiovascular and renal benefits of novel antidiabetic drugs, sodium glucose cotransporter type 2 (SGLT2) inhibitors, in type 2 diabetes. Evidence acquisition The literature published in PubMed, Scopus, Web of Science, Google Scholar, and Cochrane library were reviewed up to January 2019. The keywords including SGLT2 inhibitor, type 2 diabetes, cardiovascular effect, and renal effect were used in different combinations. Results Cardiovascular disease represents a large health burden in patients with diabetes. The prevention of cardiovascular events is a major concern in the treatment of patients with diabetes. Diabetes is also associated with an increased risk of adverse renal events and diabetic nephropathy is the leading cause of end-stage renal disease worldwide. SGLT2 inhibitors as new glucose-lowering agents act by inhibiting glucose reabsorption in the proximal tubule of the kidney, which is independent of insulin secretion. We reviewed the cardiovascular effects of these drugs including effects on triple MACE (major adverse cardiovascular events), myocardial infarction, heart failure, cardiovascular and all-cause mortality, and stroke, as well as renal effects including albuminuria, serum creatinine, the rate of renal replacement therapy, and renal function over time, along with the mechanisms of these effects. Conclusions Given the suboptimal glycemic and cardiovascular risk control in type 2 diabetes, novel therapies such as SGLT2 inhibitors seem to have an important clinical advantage to improve glycemic control and cardiovascular and renal outcomes.
- Subjects :
- Sodium-Glucose Cotransporter 2 Inhibitors
medicine.medical_specialty
Kidney
business.industry
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Renal function
Type 2 diabetes
Review Article
medicine.disease
Renal glucose reabsorption
Diabetic nephropathy
medicine.anatomical_structure
Internal medicine
Diabetes mellitus
Cardiovascular Disease
Chronic Kidney Disease
medicine
Albuminuria
Diabetes Mellitus
Renal replacement therapy
medicine.symptom
business
Subjects
Details
- ISSN :
- 1726913X
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- International journal of endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....933fba77f835fc41004d3303204bd63e