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Immunohistochemical and FISH analysis of EGFR and its prognostic value in patients with oral squamous cell carcinoma
- Source :
- Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 43(3)
- Publication Year :
- 2013
-
Abstract
- Objectives To study immunohistochemical expression of the epithelial growth factor receptor (EGFR) in oral carcinomas and the head and neck region to examine possible associations with various features of the tumors and survival of the patients. Materials and methods Sections were made from two tissue arrays composed of 206 oral squamous cell carcinomas and 427 squamous cell carcinomas of the head and neck region, respectively, and examined for EGFR expression and Ki-67 labeling index by means of immunohistochemistry, and for EGFR gene amplification by means of fluorescence in situ hybridization. Correlation between resulting parameters and with clinical features was evaluated using chi-square test and Kaplan–Meyer analysis. Results A statistically significant association was observed for strong EGFR immunohistochemical (IHC) expression with advanced lymph node involvement (P = 0.02). EGFR immunohistochemical expression did not significantly correlate with patient disease specific (DS) or overall survival (OS). EGFR gene amplification was not correlated with any of the tumor features nor to survival of the patients (DS and OS). Discussion Epithelial growth factor receptor IHC expression and gene amplification might be suitable to predict locoregional control in oral squamous cell carcinoma patients but an inappropriate predictor for patients survival.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Cell
Disease-Free Survival
Pathology and Forensic Medicine
Young Adult
Growth factor receptor
Gene duplication
medicine
Humans
EGFR Gene Amplification
Lymph node
In Situ Hybridization, Fluorescence
Aged
Neoplasm Staging
Aged, 80 and over
medicine.diagnostic_test
business.industry
Gene Amplification
Middle Aged
medicine.disease
Prognosis
Head and neck squamous-cell carcinoma
Immunohistochemistry
ErbB Receptors
Survival Rate
medicine.anatomical_structure
Ki-67 Antigen
Otorhinolaryngology
Head and Neck Neoplasms
Lymphatic Metastasis
Carcinoma, Squamous Cell
Periodontics
Female
Mouth Neoplasms
Lymph Nodes
Oral Surgery
Neoplasm Grading
business
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 16000714
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
- Accession number :
- edsair.doi.dedup.....9346c4d885f04c45b47905fbad5dc9a8