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Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents

Authors :
Samantha M, Olson
Margaret M, Newhams
Natasha B, Halasa
Ashley M, Price
Julie A, Boom
Leila C, Sahni
Pia S, Pannaraj
Katherine, Irby
Tracie C, Walker
Stephanie P, Schwartz
Aline B, Maddux
Elizabeth H, Mack
Tamara T, Bradford
Jennifer E, Schuster
Ryan A, Nofziger
Melissa A, Cameron
Kathleen, Chiotos
Melissa L, Cullimore
Shira J, Gertz
Emily R, Levy
Michele, Kong
Natalie Z, Cvijanovich
Mary A, Staat
Satoshi, Kamidani
Brandon M, Chatani
Samina S, Bhumbra
Katherine E, Bline
Mary G, Gaspers
Charlotte V, Hobbs
Sabrina M, Heidemann
Mia, Maamari
Heidi R, Flori
Janet R, Hume
Matt S, Zinter
Kelly N, Michelson
Laura D, Zambrano
Angela P, Campbell
Manish M, Patel
Adrienne G, Randolph
Source :
The New England Journal of Medicine
Publication Year :
2022
Publisher :
Massachusetts Medical Society, 2022.

Abstract

The increasing incidence of pediatric hospitalizations associated with coronavirus disease 2019 (Covid-19) caused by the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States has offered an opportunity to assess the real-world effectiveness of the BNT162b2 messenger RNA vaccine in adolescents between 12 and 18 years of age.We used a case-control, test-negative design to assess vaccine effectiveness against Covid-19 resulting in hospitalization, admission to an intensive care unit (ICU), the use of life-supporting interventions (mechanical ventilation, vasopressors, and extracorporeal membrane oxygenation), or death. Between July 1 and October 25, 2021, we screened admission logs for eligible case patients with laboratory-confirmed Covid-19 at 31 hospitals in 23 states. We estimated vaccine effectiveness by comparing the odds of antecedent full vaccination (two doses of BNT162b2) in case patients as compared with two hospital-based control groups: patients who had Covid-19-like symptoms but negative results on testing for SARS-CoV-2 (test-negative) and patients who did not have Covid-19-like symptoms (syndrome-negative).A total of 445 case patients and 777 controls were enrolled. Overall, 17 case patients (4%) and 282 controls (36%) had been fully vaccinated. Of the case patients, 180 (40%) were admitted to the ICU, and 127 (29%) required life support; only 2 patients in the ICU had been fully vaccinated. The overall effectiveness of the BNT162b2 vaccine against hospitalization for Covid-19 was 94% (95% confidence interval [CI], 90 to 96); the effectiveness was 95% (95% CI, 91 to 97) among test-negative controls and 94% (95% CI, 89 to 96) among syndrome-negative controls. The effectiveness was 98% against ICU admission and 98% against Covid-19 resulting in the receipt of life support. All 7 deaths occurred in patients who were unvaccinated.Among hospitalized adolescent patients, two doses of the BNT162b2 vaccine were highly effective against Covid-19-related hospitalization and ICU admission or the receipt of life support. (Funded by the Centers for Disease Control and Prevention.).

Details

ISSN :
15334406 and 00284793
Volume :
386
Database :
OpenAIRE
Journal :
New England Journal of Medicine
Accession number :
edsair.doi.dedup.....9359145a60f0ad9cfd29a1c245674907
Full Text :
https://doi.org/10.1056/nejmoa2117995