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Differential Proteomic Analysis of the Hippocampus in Rats with Neuropathic Pain to Investigate the Use of Electroacupuncture in Relieving Mechanical Allodynia and Cognitive Decline
- Source :
- Neural Plasticity, Neural Plasticity, Vol 2021 (2021)
- Publication Year :
- 2021
- Publisher :
- Hindawi, 2021.
-
Abstract
- Abnormal changes in hippocampal function and neuroplasticity are involved in neuropathic pain, which induces hyperalgesia and learning and memory deficits. Previous studies from our group have shown that electroacupuncture at Huantiao (GB30) and Yanglingquan (GB34) has an obvious analgesic effect on neuropathic pain. However, the central regulatory mechanism occurring in the hippocampus remains to be investigated. In this study, behavioral and proteomic analyses were performed to identify differentially expressed hippocampal proteins involved in electroacupuncture-induced analgesia. Our results showed both upregulated (TMEM126A, RDH13, and Luc7L) and downregulated proteins (Mettl7A, GGA1 RTKN, RSBN1, and CDKN1B). Further protein verification revealed for the first time that hippocampal TMEM126A plays an important anti-inflammatory role in the treatment of neuralgia by electroacupuncture.
- Subjects :
- Male
Proteomics
Article Subject
Electroacupuncture
medicine.medical_treatment
Hippocampus
Neurosciences. Biological psychiatry. Neuropsychiatry
Hippocampal formation
Rats, Sprague-Dawley
Tandem Mass Spectrometry
Neuroplasticity
medicine
Animals
Pain Management
Cognitive Dysfunction
Cognitive decline
business.industry
medicine.disease
Rats
Neurology
Hyperalgesia
Neuropathic pain
Neuralgia
Neurology (clinical)
medicine.symptom
business
Neuroscience
RC321-571
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20905904
- Database :
- OpenAIRE
- Journal :
- Neural Plasticity
- Accession number :
- edsair.doi.dedup.....936614ea53b5ad0890df3313362f49a6
- Full Text :
- https://doi.org/10.1155/2021/5597163