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Vitamin D Levels and the Risk of Posttransplant Diabetes Mellitus After Kidney Transplantation
- Source :
- Progress in Transplantation (Aliso Viejo, Calif.)
- Publication Year :
- 2021
- Publisher :
- SAGE Publications, 2021.
-
Abstract
- Introduction: Given the burden of posttransplant diabetes mellitus and the high prevalence of low vitamin D levels in kidney transplant recipients, it is reasonable to consider vitamin D as a novel and potentially modifiable risk factor in this patient population. Research question: To determine the association between 25- hydroxyvitamin D (25(OH)D) level and posttransplant diabetes among kidney transplant recipients. Design: In a multi-center cohort study of 442 patients who received a kidney transplant between January 1, 2005 and December 31, 2010, serum samples within one-year before transplant were analyzed for 25(OH)D levels. The association between 25(OH)D and posttransplant diabetes were examined in Cox proportional hazard models. Results: The median 25(OH)D level was 66 nmol/L. The cumulative probability of diabetes at 12-months by quartiles of 25(OH)D (< 42, 42 to 64.9, 65 to 94.9, and > 95 nmol/L) were 23.4%, 26.9%, 21.4%, and 15.6%, respectively. Compared to the highest 25(OH)D quartile, hazard ratios (95% CI) for the risk were 1.85 (1.03, 3.32), 2.01 (1.12, 3.60), 1.77 (0.96, 3.25) across the first to third quartiles, respectively. The associations were accentuated in a model restricted to patients on tacrolimus. When modeled as a continuous variable, 25(OH)D levels were significantly associated with a higher risk of diabetes (hazard ratio 1.06, 95% CI: 1.01, 1.13 per 10 nmol/L decrease). Discussion: Serum 25(OH)D was an independent predictor of posttransplant diabetes in kidney transplant recipients. These results may inform the design of trials using vitamin D to reduce the risk in kidney transplant recipients.
- Subjects :
- medicine.medical_specialty
kidney transplantation
030209 endocrinology & metabolism
Kidney transplant
Gastroenterology
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes Mellitus
Vitamin D and neurology
medicine
Humans
030212 general & internal medicine
Kidney transplantation
Transplantation
High prevalence
business.industry
Research
vitamin d
Vitamins
Posttransplant diabetes mellitus
medicine.disease
post-transplant diabetes mellitus
Post transplant diabetes mellitus
business
Subjects
Details
- ISSN :
- 21646708 and 15269248
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Progress in Transplantation
- Accession number :
- edsair.doi.dedup.....936a03ba08be85c4fa3ac1c56f888873