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Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning
- Source :
- The British Journal of Ophthalmology
- Publication Year :
- 2018
- Publisher :
- BMJ Publishing Group, 2018.
-
Abstract
- Glaucoma is one of the leading causes of vision loss in the world. Currently, pharmacological intervention for glaucoma therapy is limited to eye drops that reduce intraocular pressure (IOP). Recent studies have shown that various factors as well as IOP are involved in the pathogenesis of glaucoma, especially in the subtype of normal tension glaucoma. To date, various animal models of glaucoma have been established, including glutamate/aspartate transporter knockout (KO) mice, excitatory amino acid carrier 1 KO mice, optineurin E50K knock-in mice, DBA/2J mice and experimentally induced models. These animal models are very useful for elucidating the pathogenesis of glaucoma and for identifying potential therapeutic targets. However, each model represents only some aspects of glaucoma, never the whole disease. This review will summarise the benefits and limitations of using disease models of glaucoma and recent basic research in retinal protection using existing drugs.
- Subjects :
- Intraocular pressure
genetic structures
Glaucoma
degeneration
Disease
Review
Bioinformatics
drugs
experimental – animal models
Pathogenesis
Animals, Genetically Modified
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
experimental – laboratory
Normal tension glaucoma
medicine
Animals
Humans
Genetically modified animal
Antihypertensive Agents
Optineurin
business.industry
Drug Repositioning
medicine.disease
Sensory Systems
eye diseases
Ophthalmology
Drug repositioning
Disease Models, Animal
Pharmaceutical Preparations
030221 ophthalmology & optometry
sense organs
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14682079 and 00071161
- Volume :
- 103
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The British Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....938d0a67f11805e6ff1d9ae2750b803c