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Long-Term Effect of N -Acetyl-Seryl-Aspartyl-Lysyl-Proline on Left Ventricular Collagen Deposition in Rats With 2-Kidney, 1-Clip Hypertension
- Source :
- Circulation. 103:3136-3141
- Publication Year :
- 2001
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2001.
-
Abstract
- Background — N -acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Ac-SDKP plasma concentration is increased 5-fold after angiotensin-converting enzyme inhibition. Here we studied the effect of Ac-SDKP on monocyte/macrophage infiltration, fibroblast proliferation, and collagen deposition in the rat heart in renovascular hypertension. Methods and Results —We investigated whether long-term Ac-SDKP administration would prevent left ventricular (LV) hypertrophy and interstitial collagen deposition in rats with 2-kidney, 1-clip (2K-1C) hypertension. Ac-SDKP (400 μg · kg −1 · d −1 ) did not affect development of hypertension. Mean blood pressure was similar in rats with 2K-1C hypertension whether they were given vehicle or Ac-SDKP and was higher than in controls. Both LV weight and cardiomyocyte size were significantly increased in rats with 2K-1C hypertension compared with controls and were unaffected by Ac-SDKP. Proliferating cell nuclear antigen- and monocyte/macrophage-positive cells were increased in the LV of 2K-1C hypertensive rats; this increase was significantly blunted by Ac-SDKP ( P P P Conclusions —Ac-SDKP inhibited monocyte/macrophage infiltration, cell proliferation, and collagen deposition in the LV of hypertensive rats without affecting blood pressure or cardiac hypertrophy, suggesting that it may be partly responsible for the cardioprotective effect of angiotensin-converting enzyme inhibitors.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Heart Ventricles
Blood Pressure
Article
Monocytes
Muscle hypertrophy
Rats, Sprague-Dawley
Pathogenesis
Heart Rate
Physiology (medical)
Internal medicine
Renin–angiotensin system
medicine
Animals
Proline
Kidney
Oligopeptide
Dose-Response Relationship, Drug
business.industry
Macrophages
Myocardium
Heart
Hematopoietic stem cell proliferation
Rats
Dose–response relationship
Hypertension, Renovascular
medicine.anatomical_structure
Endocrinology
Hypertrophy, Left Ventricular
Collagen
Cardiology and Cardiovascular Medicine
business
Oligopeptides
Cell Division
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....93919a38b01cb2d8624f932c5089aa5b