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Spatiotemporal regulation of the Pak1 kinase

Authors :
J. de Gunzburg
Maria Carla Parrini
Michiyuki Matsuda
Source :
Biochemical Society Transactions. 33:646-648
Publication Year :
2005
Publisher :
Portland Press Ltd., 2005.

Abstract

Pak1 (p21-activated kinase 1) is a key regulator of the actin cytoskeleton, adhesion and cell motility. Such biological roles require a tight spatial and kinetic control of its localization and activity. We summarize here the current knowledge on Pak1 dynamics in vivo. Inactive dimeric Pak1 is mainly cytosolic. Localized interaction with the activators Cdc42-GTP and Rac1-GTP stimulates the kinase at the sites of cellular protrusions. Moreover, Pak1 is dynamically engaged into multiprotein complexes forming adhesions to the extracellular matrix. Cutting edge microscopy technologies on living cells are finally shedding light on the intricate spatiotemporal mechanisms regulating Pak1.

Details

ISSN :
14708752 and 03005127
Volume :
33
Database :
OpenAIRE
Journal :
Biochemical Society Transactions
Accession number :
edsair.doi.dedup.....93a08ad93e6d7591c02953616705c328
Full Text :
https://doi.org/10.1042/bst0330646