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Treatment of pediatric intracranial aneurysms: case series and meta-analysis
- Source :
- Journal of NeuroInterventional Surgery. 11:257-264
- Publication Year :
- 2018
- Publisher :
- BMJ, 2018.
-
Abstract
- BackgroundThere are limited outcome data to guide the choice of treatment in pediatric patients with cerebral aneurysms.ObjectiveTo describe our institutional experience treating pediatric patients with cerebral aneurysms and to conduct a meta-analysis of available studies to provide the best current evidence on treatment related outcomes.MethodsWe identified pediatric patients with cerebral aneurysms evaluated or treated at our institution using a comprehensive case log. We also identified studies to include in a meta-analysis through a systematic search of Pubmed, SCOPUS, EMBASE, and the Cochrane Database of Systematic Reviews. As part of both the local analysis and meta-analysis, we recorded patient characteristics, aneurysm characteristics, management, and outcomes. Statistical analysis was performed using Fisher’s exact test and the two tailed Student’s t test, as appropriate.Results42 pediatric patients with 57 aneurysms were evaluated at our institution, and treatment specific outcome data were available in 560 patients as part of our meta-analysis. Endovascular and surgical treatments yielded comparable rates of favorable outcome in all children (88.3% vs 82.7%, respectively, P=0.097), in children with ruptured aneurysms (75% vs 83%, respectively, P=0.357), and in children with unruptured aneurysms (96% vs 97%, respectively, P=1.000).ConclusionEndovascular and surgical treatment yield comparable long term clinical outcomes in pediatric patients with cerebral aneurysms.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
Databases, Factual
Ruptured aneurysms
Patient characteristics
Aneurysm, Ruptured
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Aneurysm
Case log
medicine
Humans
Favorable outcome
Child
business.industry
Endovascular Procedures
Infant
Intracranial Aneurysm
General Medicine
medicine.disease
Embolization, Therapeutic
Exact test
Treatment Outcome
Systematic review
Child, Preschool
Meta-analysis
Female
Surgery
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 17598486 and 17598478
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of NeuroInterventional Surgery
- Accession number :
- edsair.doi.dedup.....93af2d514445b59dae514fca5e94d5b8