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Risk factors of lymphovascular invasion in hypopharyngeal squamous cell carcinoma and its influence on prognosis
- Source :
- European Archives of Oto-Rhino-Laryngology. 279:1473-1479
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Lymphatic vascular invasion (LVI) is a poor prognostic factor for hypopharyngeal squamous cell carcinoma (HPSCC), but the risk factors of LVI and its relationship with clinicopathological of HPSCC remain unclear. This study aims to explore these issues. We retrospectively analyzed the clinicopathological data of 170 patients with HPSCC from January 2011 to December 2015. The relationship between LVI and clinicopathologic was analyzed by Chi-square test or Fisher’s exact test. The risk factors of LVI were examined using a logistic regression model, while risk factors of survival rate were carried out using the Cox regression model. LVI occurred in 59 cases (34.7%). In multivariate analysis, T3–4 stage (HR = 2.877; 95% CI: 1.379–6.004; p = 0.005), N2–3 stage (HR = 2.325; 95% CI: 1.120–4.824; p = 0.024), and poor differentiation (HR = 2.983; 95% CI: 1.229–7.242; p = 0.016) were independent risk factors for LVI; positive LVI was an independent risk factor for local recurrence (HR = 2.488; 95% CI: 1.150–5.383; p = 0.021), poor 5-year OS (HR = 0.375; 95% CI: 0.232–0.606; p
- Subjects :
- Oncology
medicine.medical_specialty
Multivariate analysis
Lymphovascular invasion
Logistic regression
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Neoplasm Invasiveness
Risk factor
Stage (cooking)
030223 otorhinolaryngology
Survival rate
Neoplasm Staging
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
business.industry
Proportional hazards model
General Medicine
Prognosis
Exact test
Otorhinolaryngology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
business
Subjects
Details
- ISSN :
- 14344726 and 09374477
- Volume :
- 279
- Database :
- OpenAIRE
- Journal :
- European Archives of Oto-Rhino-Laryngology
- Accession number :
- edsair.doi.dedup.....93b078cc7c2507eca706db47dabd6a59