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Comparison of Efficacy of Difluprednate 0.05% and Loteprednol Gel 0.5% After Cataract Surgery
- Source :
- Eyecontact lens. 44
- Publication Year :
- 2017
-
Abstract
- To compare the outcomes and complications of topical difluprednate 0.05% and loteprednol gel 0.5% after routine cataract surgery.Subjects received either difluprednate emulsion 0.05% (n=30 eyes) or loteprednol gel 0.5% (n=30 eyes) after routine cataract surgery. Topical steroid drops were initiated 3 days before cataract surgery and continued for 2 weeks postoperatively. Anterior chamber (AC) cell grade, corneal edema, corneal pachymetry, visual acuity, ocular surface quality (Oxford scale), and intraocular pressure (IOP) were evaluated at 1 day, 1 week, and 1 month postoperatively.Patients treated with difluprednate or loteprednol had statistically similar resolution of their AC cell grade and corneal edema at 1 day, 1 week, and 1 month postoperatively (P0.05 at each study visit). Difluprednate-treated and loteprednol-treated eyes achieved a mean best-corrected visual acuity of at least 20/25 by 1 week postoperatively (0.055 and 0.061 logarithm of the minimum angle of resolution, respectively; P=0.82). The nasal ocular surface quality at 1 week had improved in loteprednol-treated eyes compared with difluprednate-treated eyes (1.0 vs. 1.9 Oxford score, respectively; P0.001), but similar at all other visits. There was no statistical difference between IOP levels between both treatment groups (P0.05). In the difluprednate-treated group, one patient developed rebound inflammation and two patients developed cystoid macular edema at their 1-month postoperative visit.The anti-inflammatory effect, visual recovery, and IOP of patients using topical difluprednate or loteprednol gel after cataract surgery are equivalent. There may be an additional short-term benefit of loteprednol gel in protecting the ocular surface after cataract surgery.
- Subjects :
- Male
medicine.medical_specialty
Intraocular pressure
Visual acuity
genetic structures
Eye Diseases
Anterior Chamber
medicine.medical_treatment
Anti-Inflammatory Agents
Visual Acuity
Cataract Extraction
Cornea
03 medical and health sciences
0302 clinical medicine
Postoperative Complications
Ophthalmology
medicine
Humans
Corneal pachymetry
Macular edema
Glucocorticoids
Intraocular Pressure
Aged
Aged, 80 and over
Inflammation
Difluprednate
medicine.diagnostic_test
business.industry
Loteprednol Etabonate
Corneal Edema
Cataract surgery
Middle Aged
medicine.disease
eye diseases
Surgery
Loteprednol
030221 ophthalmology & optometry
Female
sense organs
medicine.symptom
Fluprednisolone
business
Gels
030217 neurology & neurosurgery
Topical steroid
medicine.drug
Subjects
Details
- ISSN :
- 1542233X
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Eyecontact lens
- Accession number :
- edsair.doi.dedup.....93c6aa94dd65bc41e34edbccc6b43e9f