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Two New Austocystin Analogs from the Marine‐Derived Fungus Aspergillus sp. WHUF05236
- Source :
- Chemistry & Biodiversity. 19
- Publication Year :
- 2022
- Publisher :
- Wiley, 2022.
-
Abstract
- Two new austocystin analogs, austocystin P (1) and austocystin Q (2), along with fourteen known compounds (3-16) were isolated from the fermentation extract of Aspergillus sp. WHUF05236. The planar structures of 1 and 2 were elucidated through 1D, 2D NMR and MS analyses. Their absolute configurations were determined by the time-dependent density functional (TDDFT)-ECD calculation. Compounds 3, 11, and 12 exhibited antimicrobial activities against Helicobacter pylori with MIC values ranging from 20.00 to 43.47 μM. Compounds 3, 6, and 7 showed cytotoxicities against the human colon cancer cell lines Hct-116 with IC
Details
- ISSN :
- 16121880 and 16121872
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Chemistry & Biodiversity
- Accession number :
- edsair.doi.dedup.....93cdda35d6c195b3885ae5b25dd9fc11