Back to Search
Start Over
Serum vitamin D and hippocampal gray matter volume in schizophrenia
- Source :
- Psychiatry Research: Neuroimaging. 233:175-179
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Disparate lines of evidence including epidemiological and case-control studies have increasingly implicated vitamin D in the pathogenesis of schizophrenia. Vitamin D deficiency can lead to dysfunction of the hippocampus--a brain region hypothesized to be critically involved in schizophrenia. In this study, we examined for potential association between serum vitamin D level and hippocampal gray matter volume in antipsychotic-naïve or antipsychotic-free schizophrenia patients (n = 35). Serum vitamin D level was estimated using 25-OH vitamin D immunoassay. Optimized voxel-based morphometry was used to analyze 3-Tesla magnetic resonance imaging (MRI) (1-mm slice thickness). Ninety-seven percent of the schizophrenia patients (n = 34) had sub-optimal levels of serum vitamin D (83%, deficiency; 14%, insufficiency). A significant positive correlation was seen between vitamin D and regional gray matter volume in the right hippocampus after controlling for age, years of education and total intracranial volume (Montreal Neurological Institute (MNI) coordinates: x = 35, y = -18, z = -8; t = 4.34 pFWE(Corrected) = 0.018). These observations support a potential role of vitamin D deficiency in mediating hippocampal volume deficits, possibly through neurotrophic, neuroimmunomodulatory and glutamatergic effects.
- Subjects :
- Adult
Male
medicine.medical_specialty
Statistics as Topic
Neuroscience (miscellaneous)
Hippocampal formation
Hippocampus
vitamin D deficiency
Pathogenesis
Risk Factors
Internal medicine
medicine
Vitamin D and neurology
Humans
Radiology, Nuclear Medicine and imaging
Gray Matter
Vitamin D
Serum vitamin
medicine.diagnostic_test
biology
Magnetic resonance imaging
Organ Size
Vitamin D Deficiency
medicine.disease
Magnetic Resonance Imaging
Psychiatry and Mental health
Serum vitamin D level
Endocrinology
Schizophrenia
biology.protein
Receptors, Calcitriol
Female
Psychology
Neurotrophin
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....93d32dbd76c17a39fcc6383be3952fb0