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Mass spectrometry for the evaluation of cardiovascular diseases based on proteomics and lipidomics
- Source :
- Thrombosis and Haemostasis, Vol. 106, No 1 (2011) pp. 20-33, Thrombosis and haemostasis
- Publication Year :
- 2011
-
Abstract
- SummaryThe identification and quantification of proteins and lipids is of major importance for the diagnosis, prognosis and understanding of the molecular mechanisms involved in disease development. Owing to its selectivity and sensitivity, mass spectrometry has become a key technique in analytical platforms for proteomic and lipidomic investigations. Using this technique, many strategies have been developed based on unbiased or targeted approaches to highlight or monitor molecules of interest from biomatrices. Although these approaches have largely been employed in cancer research, this type of investigation has been met by a growing interest in the field of cardiovascular disorders, potentially leading to the discovery of novel biomarkers and the development of new therapies. In this paper, we will review the different mass spectrometry- based proteomic and lipidomic strategies applied in cardiovascular diseases, especially atherosclerosis. Particular attention will be given to recent developments and the role of bioinformatics in data treatment. This review will be of broad interest to the medical community by providing a tutorial of how mass spectrometric strategies can support clinical trials.
- Subjects :
- Proteomics
0301 basic medicine
Biological Markers/metabolism
Disease
Bioinformatics
Mass spectrometry
Mass spectrometry imaging
Mass Spectrometry
03 medical and health sciences
Lipids/analysis
Lipidomics
Drug Discovery
Medicine
Humans
ddc:616
ddc:615
Clinical Trials as Topic
030102 biochemistry & molecular biology
business.industry
Drug discovery
ddc:614.1
Computational Biology
Hematology
Atherosclerosis
Lipid Metabolism
Prognosis
Lipids
Mass spectrometric
3. Good health
030104 developmental biology
Cardiovascular Diseases
Cardiovascular Diseases/diagnosis/drug therapy/metabolism
Atherosclerosis/diagnosis/drug therapy/metabolism
Identification (biology)
Proteomics/methods
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 03406245
- Database :
- OpenAIRE
- Journal :
- Thrombosis and Haemostasis, Vol. 106, No 1 (2011) pp. 20-33, Thrombosis and haemostasis
- Accession number :
- edsair.doi.dedup.....93e0904507281617105985c54785eb0b