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Reevaluating the Role of the Hippocampus in Delay Eyeblink Conditioning
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 8, p e71249 (2013)
- Publication Year :
- 2013
- Publisher :
- Public Library of Science, 2013.
-
Abstract
- The role of the hippocampus in delay eyeblink conditioning (DEC) remains controversial. Here, we investigated the involvement of the hippocampus in DEC with a soft tone as the conditioned stimulus (CS) by using electrolytic lesions or muscimol inactivation of guinea pig dorsal hippocampus. Interestingly, when a soft tone was used as a CS, electrolytic lesions of the hippocampus significantly retarded acquisition of the conditioned response (CR), and muscimol infusions into hippocampus distinctly inhibited the acquisition and expression of CR, but had no significant effect on consolidation of well-learned CR. In contrast, both electrolytic lesions and muscimol inactivation of hippocampus produced no significant deficits in the CR when a loud tone was used as the CS. These results demonstrate that the hippocampus is essential for the DEC when the delay task was rendered more difficult.
- Subjects :
- Central Nervous System
Anatomy and Physiology
Conditioning, Classical
Guinea Pigs
lcsh:Medicine
Hippocampus
Neurological System
Guinea pig
Stereotaxic Techniques
chemistry.chemical_compound
Model Organisms
Learning and Memory
Neural Pathways
Animals
lcsh:Science
Biology
GABA Agonists
Multidisciplinary
Behavior, Animal
Blinking
Muscimol
lcsh:R
Conditioned response
Classical conditioning
Animal Models
Connectomics
Animal Cognition
Conditioning, Eyelid
Neuroanatomy
Eyeblink conditioning
chemistry
nervous system
Pattern Recognition, Physiological
Stereotaxic technique
lcsh:Q
Female
Analysis of variance
Neuroscience
psychological phenomena and processes
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....93e0ea4e672edbd1ba6153d6a6e8db52