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The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct
The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct
- Source :
- Immunity. (2):193-204
- Publisher :
- Cell Press.
-
Abstract
- Memory T cells are divided into central and effector subsets with distinct functions and homing capabilities. We analyzed the composition and dynamics of the CD8 + T cell repertoire of these subsets within the peripheral blood of four healthy individuals. Both subsets had largely distinct and autonomous TCRβ repertoires. Their composition remained stable over a 9 month period, during which no cell passage between these subsets was detected despite important size variation of several clones. In one donor, four out of six TCRβ clonotypes specific for the influenza A virus were detected in the central subset only, while the two others were shared. Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset.
- Subjects :
- Adult
Time Factors
Cellular differentiation
Immunology
Biology
CD8-Positive T-Lymphocytes
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
T-Lymphocyte Subsets
Influenza A virus
medicine
Immunology and Allergy
Humans
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
L-Selectin
030304 developmental biology
Genetics
0303 health sciences
Base Sequence
Effector
Effector Memory T-Cell
Models, Immunological
Cell Differentiation
DNA
Middle Aged
3. Good health
Infectious Diseases
Cell culture
biology.protein
Leukocyte Common Antigens
L-selectin
Immunologic Memory
CD8
030215 immunology
Homing (hematopoietic)
Subjects
Details
- Language :
- English
- ISSN :
- 10747613
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Immunity
- Accession number :
- edsair.doi.dedup.....93e1f518bf91b285b91d79377eb5f8fd
- Full Text :
- https://doi.org/10.1016/S1074-7613(03)00020-7