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The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

The Repertoires of Circulating Human CD8+ Central and Effector Memory T Cell Subsets Are Largely Distinct

Authors :
Ana Cumano
Philippe Kourilsky
Véronique Baron
Cécile Bouneaud
T. Petteri Arstila
Laurent Ferradini
Annick Lim
Christophe Pannetier
Source :
Immunity. (2):193-204
Publisher :
Cell Press.

Abstract

Memory T cells are divided into central and effector subsets with distinct functions and homing capabilities. We analyzed the composition and dynamics of the CD8 + T cell repertoire of these subsets within the peripheral blood of four healthy individuals. Both subsets had largely distinct and autonomous TCRβ repertoires. Their composition remained stable over a 9 month period, during which no cell passage between these subsets was detected despite important size variation of several clones. In one donor, four out of six TCRβ clonotypes specific for the influenza A virus were detected in the central subset only, while the two others were shared. Altogether, these observations suggest that most effector memory T cells may not have derived from the central memory subset.

Details

Language :
English
ISSN :
10747613
Issue :
2
Database :
OpenAIRE
Journal :
Immunity
Accession number :
edsair.doi.dedup.....93e1f518bf91b285b91d79377eb5f8fd
Full Text :
https://doi.org/10.1016/S1074-7613(03)00020-7