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Microvascular and lymphovascular tumour invasion are associated with poor prognosis and metastatic spread in renal cell carcinoma: a validation study in clinical practice

Authors :
Marcus Scharpf
Steffen Rausch
Frank Dombrowski
Shahrokh F. Shariat
Silvia Ribback
Johannes Heide
Andrea Haitel
Jens Bedke
Nils Kroeger
Martin Burchardt
Uwe Zimmermann
Arnulf Stenzl
Maik Pechoel
Hussam Alkhayyat
Tobias Klatte
Michela de Martino
Source :
BJU International. 121:84-92
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Objective To validate microvascular (MVI) and lymphovascular (LVI) invasion as a prognostic factor in renal cell carcinoma patients (pts.) Materials and Methods Data of patients with RCC who underwent radical or nephron sparing surgery were prospectively collected from three academic centers. The occurrence of MVI and LVI was determined with standard staining protocols by experienced pathologists at the time of diagnosis. The association of MVI and LVI with clinicopathological data, metastatic spread and cancer-specific survival (CSS) was evaluated with Fisher's exact tests, binary logistic regression analyses and univariable and multivariable Cox proportional hazard regression models. Results MVI was present in 201 of 747 (26.9%) pts. and was associated with advanced TNM stages, high Fuhrman grades and sarcomatoid features (each p

Details

ISSN :
14644096
Volume :
121
Database :
OpenAIRE
Journal :
BJU International
Accession number :
edsair.doi.dedup.....93eda87d80c4b57bdfa552f319290c68
Full Text :
https://doi.org/10.1111/bju.13984