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Microvascular and lymphovascular tumour invasion are associated with poor prognosis and metastatic spread in renal cell carcinoma: a validation study in clinical practice
- Source :
- BJU International. 121:84-92
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Objective To validate microvascular (MVI) and lymphovascular (LVI) invasion as a prognostic factor in renal cell carcinoma patients (pts.) Materials and Methods Data of patients with RCC who underwent radical or nephron sparing surgery were prospectively collected from three academic centers. The occurrence of MVI and LVI was determined with standard staining protocols by experienced pathologists at the time of diagnosis. The association of MVI and LVI with clinicopathological data, metastatic spread and cancer-specific survival (CSS) was evaluated with Fisher's exact tests, binary logistic regression analyses and univariable and multivariable Cox proportional hazard regression models. Results MVI was present in 201 of 747 (26.9%) pts. and was associated with advanced TNM stages, high Fuhrman grades and sarcomatoid features (each p
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Pathology
Lymphovascular invasion
Urology
medicine.medical_treatment
030232 urology & nephrology
Kaplan-Meier Estimate
Nephrectomy
Disease-Free Survival
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Renal cell carcinoma
Internal medicine
medicine
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Carcinoma, Renal Cell
Survival analysis
Aged
Neoplasm Staging
Proportional Hazards Models
Retrospective Studies
Neovascularization, Pathologic
Proportional hazards model
business.industry
Hazard ratio
Odds ratio
Middle Aged
Prognosis
medicine.disease
Survival Analysis
Kidney Neoplasms
Lymphovascular
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 14644096
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- BJU International
- Accession number :
- edsair.doi.dedup.....93eda87d80c4b57bdfa552f319290c68
- Full Text :
- https://doi.org/10.1111/bju.13984