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Early impairment of insulin secretion in rats after surgical trauma
- Source :
- Karolinska Institutet
- Publication Year :
- 2002
- Publisher :
- Oxford University Press (OUP), 2002.
-
Abstract
- OBJECTIVE: Hyperglycaemia associated with insulin resistance is common after trauma and surgical procedures. Both reduced insulin sensitivity and altered insulin secretion may contribute to the impaired glucose homeostasis. We have demonstrated that skeletal muscle insulin resistance is present 2 h after small intestinal resection in rats. In this study, the aim was to investigate insulin secretion in the same experimental model. DESIGN: Small intestinal resection (5 cm) was performed in adult rats. The control animals underwent anaesthesia only. METHODS: The intravenous glucose tolerance test (IVGTT), the hyperglycaemic clamp and in vitro studies in isolated pancreatic islets were performed after surgery. Concentrations of blood glucose, plasma insulin, corticosterone and interleukin-6 (IL-6) were determined 0-5 h postoperatively. RESULTS: The insulin response in the IVGTT was attenuated 2 h (P
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
In Vitro Techniques
Arginine
Islets of Langerhans
chemistry.chemical_compound
Endocrinology
Insulin resistance
Corticosterone
Internal medicine
Insulin Secretion
Intestine, Small
Animals
Insulin
Medicine
Glucose homeostasis
Rats, Wistar
Digestive System Surgical Procedures
Pancreatic hormone
Glucose tolerance test
medicine.diagnostic_test
business.industry
Pancreatic islets
General Medicine
Glucose Tolerance Test
medicine.disease
Pathophysiology
Rats
medicine.anatomical_structure
chemistry
business
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....93fe0b604e0965d043cf87e2f738ee11