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Nadir CD4 Is Negatively Associated With Antinuclear Antibody Detection in HCV/HIV-Coinfected Patients
- Source :
- Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2019, 80 (4), pp.461-466. ⟨10.1097/QAI.0000000000001940⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2019, 80 (4), pp.461-466. ⟨10.1097/QAI.0000000000001940⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Background: Hepatitis C virus (HCV) and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. Setting: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti–smooth muscle actin (aSMA), and anti–liver kidney microsome (aLKM1) antibodies (Ab) in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era. Methods: A cross-sectional observational study nested in the ANRS CO13 HEPAVIH cohort (NCT number: NCT03324633). We selected patients with both ANA testing and T-cell immunophenotyping determination during the cohort follow-up and collected aLKM1 and aSMA data when available. Logistic regression models were built to determine factors associated with the presence of auto-Ab. Results: Two hundred twenty-three HCV/HIV-coinfected patients fulfilled selection criteria. Prevalence of ANA and aSMA was 43.5% and 23.2%, respectively, and both were detected in 13.3% of patients. Isolated aSMA were detected in 9.9% and aLKM1 in 2 patients. In multivariable analysis, only a low nadir CD4 T-cell count was significantly associated with ANA detection. Conclusions: ANA and aSMA detection remain frequent in HCV/HIV-coinfected patients during the post–combined antiretroviral therapy era, despite fair immune restoration. These results advocate for a close monitoring of ANA before immune checkpoint inhibitor therapy in these patients with greater caution for those with a low nadir CD4 T-cell count.
- Subjects :
- Male
medicine.medical_specialty
Anti-nuclear antibody
Cross-sectional study
Hepatitis C virus
T-Lymphocytes
HIV Infections
Hepacivirus
030312 virology
Logistic regression
medicine.disease_cause
Autoimmune Diseases
03 medical and health sciences
Immunophenotyping
Internal medicine
medicine
Humans
Pharmacology (medical)
anti–liver kidney microsome antibodies
non–organ-specific autoantibodies
0303 health sciences
biology
business.industry
Coinfection
anti–smooth muscle actin antibodies
Middle Aged
Hepatitis C
Actins
3. Good health
CD4 Lymphocyte Count
Infectious Diseases
Cross-Sectional Studies
autoimmune antinuclear
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Antibodies, Antinuclear
Cohort
biology.protein
HIV-1
Microsomes, Liver
Female
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
HCV–HIV coinfection
Antibody
nadir CD4
business
Nadir (topography)
Subjects
Details
- Language :
- English
- ISSN :
- 15254135 and 19447884
- Database :
- OpenAIRE
- Journal :
- Journal of Acquired Immune Deficiency Syndromes-JAIDS, Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2019, 80 (4), pp.461-466. ⟨10.1097/QAI.0000000000001940⟩, Journal of Acquired Immune Deficiency Syndromes, Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2019, 80 (4), pp.461-466. ⟨10.1097/QAI.0000000000001940⟩
- Accession number :
- edsair.doi.dedup.....9400362d2a7cff9ff94007be84221be9