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ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases
- Source :
- Journal of Molecular Biology. 433:166727
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- While variants of noncoding RNAs (ncRNAs) have been experimentally validated as a new class of biomarkers and drug targets, the discovery and interpretation of relationships between ncRNA variants and human diseases become important and challenging. Here we present ncRNAVar (http://www.liwzlab.cn/ncrnavar/), the first database that provides association data between validated ncRNA variants and human diseases through manual curation on 2650 publications and computational annotation. ncRNAVar contains 4565 associations between 711 human disease phenotypes and 3112 variants from 2597 ncRNAs. Each association was reviewed by professional curators, incorporated with valuable annotation and cross references, and designated with an association score by our refined score model. ncRNAVar offers web applications including association prioritization, network visualization, and relationship mapping. ncRNAVar, presenting a landscape of ncRNA variants in human diseases and a useful resource for subsequent software development, will improve our insight of relationships between ncRNA variants and human health.
- Subjects :
- Prioritization
Association score
RNA, Untranslated
Biology
computer.software_genre
Manual curation
03 medical and health sciences
Annotation
Human health
0302 clinical medicine
Human disease
Structural Biology
Humans
Disease
Genetic Predisposition to Disease
Molecular Biology
030304 developmental biology
Internet
0303 health sciences
Database
Genetic Variation
Non-coding RNA
Phenotype
Identification (biology)
Databases, Nucleic Acid
computer
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00222836
- Volume :
- 433
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Biology
- Accession number :
- edsair.doi.dedup.....9402bca68d952b932d3404e7cb2f913c