Inflammatory parameters and blood lipid values across the different mood states in patients with bipolar disorder (eng)

INTRODUCTION[|]Recent studies indicate the role of impairment in immune regulation and inflammatory abnormality in Bipolar Disorder (BD). However, there is a limited study reported the relationship of inflammation markers such as CRP, neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and monocyte lymphocyte ratio (MLR) with bipolar disorder. This study aims to compare these inflammatory markers and lipid values in different states of BD and healthy controls.[¤]METHODS[|]A retrospective observational study was carried out on a sample of patient admissions to the Department of Psychiatry of Usak University Hospital between November 1, 2017, and November 1, 2019, with a diagnosis of bipolar disorder in mania, depression, mixed episode, and remission. Data about Complete blood count, C Reactive Protein (CRP), and lipid values were retrieved from the electronic medical records of patients at Usak University Hospital. [¤]RESULTS[|]We found that patients with BD in depressive and mixed states had higher levels of CRP, and patients with BD in manic states had higher levels of MLR than other groups. There was no statistically significant difference at PLR and MPV values between groups. In terms of lipid levels, remitted bipolar patients had significantly higher Total Chol, TG, LDL, and VLDL levels than other patient groups and controls. [¤]DISCUSSION AND CONCLUSION[|]The present study suggests a close relationship between bipolar disorder, lipid metabolism and inflammation process. CRP may serve as a possible biomarker of mixed and depressive episodes of BD, while MLR may serve as a potential state biomarker of the manic episode. Our findings also claim that patients with BD experience impairment in lipid metabolism during remission and mixed episode and that this should be taken into account in the treatment management. Future prospective studies are needed to determine the exact role of inflammation and lipid metabolism on the different states of bipolar disorders. [¤]