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Proteomics reveals disturbances in the immune response and energy metabolism of monocytes from patients with septic shock
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Sepsis results from a dyshomeostatic response to infection, which may lead to hyper or hypoimmune states. Monocytes are central regulators of the inflammatory response, but our understanding of their role in the genesis and resolution of sepsis is still limited. Here, we report a comprehensive exploration of monocyte molecular responses in a cohort of patients with septic shock via proteomic profiling. The acute stage of septic shock was associated with an impaired inflammatory phenotype, indicated by the down-regulation of MHC class II molecules and proinflammatory cytokine pathways. Simultaneously, there was an up-regulation of glycolysis enzymes and a decrease in proteins related to the citric acid cycle and oxidative phosphorylation. On the other hand, the restoration of immunocompetence was the hallmark of recovering patients, in which an upregulation of interferon signaling pathways was a notable feature. Our results provide insights into the immunopathology of sepsis and propose that, pending future studies, immunometabolism pathway components could serve as therapeutic targets in septic patients.
- Subjects :
- 0301 basic medicine
Male
Proteomics
Immunopathogenesis
Science
Immunology
Pathogenesis
Monocytes
Article
Proinflammatory cytokine
Sepsis
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Immune system
Downregulation and upregulation
Immunopathology
medicine
Humans
Prospective Studies
Aged
Aged, 80 and over
Inflammation
Multidisciplinary
Septic shock
business.industry
Monocyte
Histocompatibility Antigens Class II
Immunity
PROTEÔMICA
Middle Aged
medicine.disease
Shock, Septic
030104 developmental biology
medicine.anatomical_structure
Case-Control Studies
Cytokines
Medicine
Female
Immunocompetence
business
Energy Metabolism
Infection
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....940ee140554d23cdfdd9c0feffaf7ffe