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Association of UGT2B7 and ABCB1 genotypes with morphine-induced adverse drug reactions in Japanese patients with cancer
- Source :
- Cancer Chemotherapy and Pharmacology. 65:251-258
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- To investigate the effects of genetic polymorphisms on morphine-induced adverse events in cancer patients. We examined the relation of morphine-related adverse events to polymorphisms in UDP-glucuronosyltransferase (UGT) 2B7, ATP-binding cassette, sub-family B, number 1 (ABCB1), and μ-opioid receptor 1 genes in 32 Japanese cancer patients receiving oral controlled-release morphine sulfate tablets. The T/T genotype at 1236 or TT/TT diplotype at 2677 and 3435 in ABCB1 was associated with significantly lower frequency of fatigue (grades 1–3) (P = 0.012 or 0.011, Fisher’s exact test). The UGT2B7*2 genotype was associated with the frequency of nausea (grades 1–3) (P = 0.023). The frequency of nausea was higher in patients without UGT2B7*2 allele than others. The diplotype at 2677 and 3435 in ABCB1 was associated with the frequency of vomiting (grades 1–3) (P = 0.011). No patient whose diplotype was consisted of no GC allele at 2677 and 3435 suffered from vomiting. Our findings suggest that pharmacogenetics can be used to predict the risk of morphine-induced adverse events.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
ATP Binding Cassette Transporter, Subfamily B
Genotype
Nausea
Receptors, Opioid, mu
Pain
Toxicology
Gastroenterology
Asian People
Japan
Neoplasms
Internal medicine
medicine
Humans
Pharmacology (medical)
ATP Binding Cassette Transporter, Subfamily B, Member 1
Glucuronosyltransferase
Allele
Adverse effect
Genetic Association Studies
Aged
Pharmacology
Polymorphism, Genetic
Morphine
business.industry
Cancer
Middle Aged
medicine.disease
Analgesics, Opioid
Exact test
Endocrinology
Oncology
Delayed-Action Preparations
Vomiting
Female
medicine.symptom
business
Pharmacogenetics
Subjects
Details
- ISSN :
- 14320843 and 03445704
- Volume :
- 65
- Database :
- OpenAIRE
- Journal :
- Cancer Chemotherapy and Pharmacology
- Accession number :
- edsair.doi.dedup.....9415bda681ce4a404e18c35b1232ac61