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Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study
- Source :
- Phytotherapy research : PTRREFERENCES.
- Publication Year :
- 2022
-
Abstract
- Isopsoralen (IPRN), which comes from the fruit of Psoralea corylifolia, has been identified as a kind of phytoestrogen and has been proven to be effective for the treatment of osteoporosis (OP). However, the mechanisms underlying IPRN's anti-OP effects, especially the anti-postmenopausal osteoporosis (PMOP) effects, remain indistinct. Thus, this study aimed to investigate the effects and mechanisms of IPRN's anti-PMOP activity. In this study, the bioinformatics results predicted that IPRN could resist PMOP by targeting EGFR, AKT1, SRC, CCND1, ESR1 (ER-α), AR, PGR, BRCA1, PTGS2, and IGF1R. An ovariectomized (OVX) mice model and a H
- Subjects :
- Pharmacology
Subjects
Details
- ISSN :
- 10991573
- Database :
- OpenAIRE
- Journal :
- Phytotherapy research : PTRREFERENCES
- Accession number :
- edsair.doi.dedup.....9418a6461e7a3236130d51d01b96444c