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Impact of genetics in childhood asthma
- Source :
- Jornal de Pediatria.
- Publication Year :
- 2008
- Publisher :
- Jornal de Pediatria, 2008.
-
Abstract
- To present the most important and recent results of studies on asthma genetics. These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy.Data were collected from MEDLINE. Genetic association studies were selected from the Genetic Association Database, which is an archive of human genetic association studies of complex diseases and disorders organized by the National Institutes of Health.Considering the data from several important twin studies on asthma genetics, heritability, which measures the contribution of genetic factors to the variance of asthma, may be estimated in 0.48-0.79. A huge number of genetic association studies have been trying to identify asthma susceptibility genes. The most replicated results in the genetic association studies involve the following five regions of the human genome: 5q31-32, 6p21, 11q12-13, 16p11-12, and 20p13. Only recently a new asthma susceptibility gene (ORMDL3) has been identified by a whole genome association study, considered to be a major determinant for childhood asthma.Genetic contribution to asthma may be estimated ranging from 48 to 79%. Several loci seem to influence asthma susceptibility. Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be determinants of childhood asthma. Diagnostics and pharmacogenetics may be the first clinical implication of extensive studies on asthma genetics.
- Subjects :
- Genetics
Childhood asthma
Genome, Human
business.industry
MEDLINE
Genome-wide association study
medicine.disease
Twin Studies as Topic
Asthma
United States
Atopy
Pharmacogenetics
Pediatrics, Perinatology and Child Health
Diseases in Twins
Chromosomes, Human
Humans
Medicine
Genetic Predisposition to Disease
Child
business
Genome-Wide Association Study
Genetic association
Subjects
Details
- ISSN :
- 00217557
- Database :
- OpenAIRE
- Journal :
- Jornal de Pediatria
- Accession number :
- edsair.doi.dedup.....942c44e9075fbaaf4dfff88e6559d19c
- Full Text :
- https://doi.org/10.2223/jped.1781