Supplemental Figures 1 - 6 from l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor Cells

Supplemental Figure 1. Peg-Arg I blocks T cell proliferation and IFNy production. Supplemental Figure 2. Peg-Arg I does not alter T cell percentages in naive mice. Supplemental Figure 3. Effects of peg-Arg I on T-cell glycolysis. Supplemental Figure 4. ASS-1 Silencing in T-cells. Supplemental Figure 5. Asparaginase depletion induces MDSC accumulation. Supplemental Figure 6. Peg-Arg I increases arginase activity in CD11b+ Gr1+ cells.