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Effectiveness and Safety of the Combined Use of Tranexamic Acid: A Comparative Observational Study of 1909 Cases
- Source :
- Indian J Orthop, Indian Journal of Orthopaedics, Vol 53, Iss 6, Pp 708-713 (2019), Indian Journal of Orthopaedics
- Publication Year :
- 2020
-
Abstract
- BACKGROUND: Tranexamic acid (TA) use in lower‑limb arthroplasty has been valued in these surgeries high‑risk hemorrhagic due to its antifibrinolytic action. The objective of the present study was to determine the effectiveness of the combined intravenous (IV) and intraarticular (IA) administration of TA in lower‑limb arthroplasty. METHODS: We conduct a prospective observational study between January 1, 2014, and December 31, 2017, including all programmed lower‑limb arthroplasties. Patients were divided into four groups: no TA, 15 mg/kg IV TA, 3 g IA TA, and 15 mg/kg IV and 3 g IA. The effect on calculated total blood loss (milliliter of red blood cell [RBC]), hemoglobin, transfusion, and duration of hospitalization was studied after adjustment on age, American Society of Anesthesiologists, surgery, and postoperative curative anticoagulation. Complications related to TA administration were systematically reported. RESULTS: A total of 1909 patients were included – “no TA,” n = 184; “IV,” n = 1137; “IA,” n = 214; and “IV + IA,” n = 374. In the IV + IA group, a decrease in blood loss was observed compared to the no TA group (+ 220 ml 95% confidence interval [CI] [184; 255] of RBC P
- Subjects :
- Antifibrinolytic
medicine.drug_class
medicine.medical_treatment
Deep vein
tranexamic acid
03 medical and health sciences
0302 clinical medicine
lcsh:Orthopedic surgery
medicine
Orthopedics and Sports Medicine
combined
030222 orthopedics
business.industry
Hazard ratio
Blood loss
Liter
030229 sport sciences
medicine.disease
Thrombosis
Arthroplasty
intraarticular
Confidence interval
lcsh:RD701-811
medicine.anatomical_structure
Anesthesia
intravenous
Original Article
business
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 00195413
- Volume :
- 54
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- Indian journal of orthopaedics
- Accession number :
- edsair.doi.dedup.....944ec0b7a50b1cd37c9b06482eab6b09