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Reduced Recurrence of Primary IgA Nephropathy in Kidney Transplant Recipients Receiving Everolimus With Corticosteroid: A Retrospective, Single-Center Study of 135 Transplant Patients
- Source :
- Transplantation Proceedings. 52:3118-3124
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Long-term kidney allograft survival remains a major clinical challenge. Recurrent glomerulonephritis disease, including recurrence of IgA nephropathy (IgAN), is a significant barrier to long-term kidney allograft survival. We performed a retrospective, observational study to evaluate the role of everolimus (EVR) in the risk of recurrent IgAN.The study included data from 135 patients aged ≥16 years with biopsy-proven IgAN on native kidneys who underwent a kidney transplant (KT) between December 2002 and December 2018.Patients who underwent de novo KT received mycophenolate mofetil (MMF) (n = 107) or EVR (n = 28). The mean recipient age in the MMF and EVR groups was 44.9 ± 13.7 and 41.1 ± 10.1, respectively. The median (interquartile range) follow-up period was 90.9 (64.9-115.3) and 21.2 (11.4-30.6) months, respectively (.0001). All patients received continuous corticosteroid and tacrolimus therapy. The death-censored graft survival rate after KT and the recurrence-free survival rate did not differ significantly between the groups. Univariate and multivariate Cox regression analyses identified EVR for de novo KT as an independent predictive factor for recurrence-free survival (P = .024).Our findings suggest that EVR-based regimens with tacrolimus and corticosteroid therapy for de novo KT reduce the recurrence of IgAN compared with MMF-based regimens with tacrolimus and corticosteroid therapy.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.drug_class
Urology
Disease
Single Center
Tacrolimus
Nephropathy
Adrenal Cortex Hormones
Recurrence
Interquartile range
Secondary Prevention
medicine
Humans
Everolimus
Aged
Retrospective Studies
Transplantation
Kidney
business.industry
Graft Survival
Glomerulonephritis, IGA
Middle Aged
Mycophenolic Acid
medicine.disease
Kidney Transplantation
medicine.anatomical_structure
Corticosteroid
Female
Surgery
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 00411345
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....94529f30886e5abc658548dd90bc7408