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Acquired intestinal aganglionosis after a lytic infection with varicella-zoster virus
- Source :
- Journal of Pediatric Surgery. 41:e29-e31
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Background and Purpose In this report, we present the first case of an immunologically impaired child surviving a lytic varicella-zoster virus infection affecting the enteric nervous system. In histological findings, myenteric and submucous enteric ganglia were nearly completely absent owing to virus infection. Methods A 3-year-old girl with acute lymphoblastic leukemia and generalized varicella-zoster infection developed an ileus. She underwent multiple laparotomies in which histological sections of the entire small intestine could be obtained. Results The histological evaluation of these samples showed a generalized aganglionosis with inflammatory residuals. A more detailed immunohistochemical analysis using neuronal (PGP, enolase), glial (S100), and lymphocytic (LCA) antibodies demonstrated a nearly complete neuronal loss. Conclusion To our knowledge, this is the first case of a secondary intestinal aganglionosis after varicella-zoster virus infection.
- Subjects :
- Pathology
medicine.medical_specialty
Ileus
viruses
Enolase
medicine.disease_cause
Herpes Zoster
Enteric Nervous System
Virus
Immunocompromised Host
Intestine, Small
Humans
Medicine
Varicella Zoster Infection
integumentary system
business.industry
Varicella zoster virus
virus diseases
General Medicine
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Intestinal Diseases
Lytic cycle
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
Immunohistochemistry
Female
Surgery
Enteric nervous system
business
Subjects
Details
- ISSN :
- 00223468
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Surgery
- Accession number :
- edsair.doi.dedup.....946019b83d6fe6e018a53027c3cbeb35