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P2X7 Receptor Signaling in Stress and Depression
- Source :
- International Journal of Molecular Sciences, Vol 20, Iss 11, p 2778 (2019), Ribeiro, D E, Roncalho, A L, Glaser, T, Ulrich, H, Wegener, G & Joca, S 2019, ' P2X7 Receptor Signaling in Stress and Depression ', International Journal of Molecular Sciences, vol. 20, no. 11 . https://doi.org/10.3390/ijms20112778, International Journal of Molecular Sciences, Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required. Recent studies suggest that adenosine triphosphate (ATP)-mediated signaling through the P2X7 receptor (P2X7R) might play a prominent role in regulating depression-related pathology, such as synaptic plasticity, neuronal degeneration, as well as changes in cognitive and behavioral functions. P2X7R is an ATP-gated cation channel localized in different cell types in the central nervous system (CNS), playing a crucial role in neuron-glia signaling. P2X7R may modulate the release of several neurotransmitters, including monoamines, nitric oxide (NO) and glutamate. Moreover, P2X7R stimulation in microglia modulates the innate immune response by activating the NLR family pyrin domain containing 3 (NLRP3) inflammasome, consistent with the neuroimmune hypothesis of MDD. Importantly, blockade of P2X7R leads to antidepressant-like effects in different animal models, which corroborates the findings that the gene encoding for the P2X7R is located in a susceptibility locus of relevance to depression in humans. This review will discuss recent findings linked to the P2X7R involvement in stress and MDD neuropathophysiology, with special emphasis on neurochemical, neuroimmune, and neuroplastic mechanisms.
- Subjects :
- 0301 basic medicine
Review
Biology
Pyrin domain
Catalysis
neuroinflammation
Inorganic Chemistry
lcsh:Chemistry
03 medical and health sciences
stress
0302 clinical medicine
Neurochemical
Neuroplasticity
NLR Family, Pyrin Domain-Containing 3 Protein
medicine
Animals
Humans
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Neuroinflammation
Neurotransmitter Agents
Organic Chemistry
Glutamate receptor
Brain
Inflammasome
General Medicine
3. Good health
Computer Science Applications
030104 developmental biology
Monoamine neurotransmitter
lcsh:Biology (General)
lcsh:QD1-999
Synaptic plasticity
P2X7 receptor
depression
ESTRESSE
Receptors, Purinergic P2X7
Neuroscience
030217 neurology & neurosurgery
Stress, Psychological
medicine.drug
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 20
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....94651b45538677fd446a327567506afa
- Full Text :
- https://doi.org/10.3390/ijms20112778