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New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules, Vol 22, Iss 1, p 133 (2017), Molecules; Volume 22; Issue 1; Pages: 133
- Publication Year :
- 2016
-
Abstract
- A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2, 3), together with two known compounds (4, 5), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 μM) exhibited significant hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays.
- Subjects :
- Antipyretics
Stereochemistry
Propanols
Pharmaceutical Science
coumarin glycoside
Hydrangea
Protective Agents
01 natural sciences
Article
Hydrangea paniculata
Analytical Chemistry
lcsh:QD241-441
chemistry.chemical_compound
Structure-Activity Relationship
lcsh:Organic chemistry
Coumarins
Drug Discovery
Humans
Glycosides
Physical and Theoretical Chemistry
hepatoprotective activity
Acetaminophen
chemistry.chemical_classification
phenylpropanoid glycoside
biology
Phenylpropanoid
Molecular Structure
Plant Stems
010405 organic chemistry
Organic Chemistry
In vitro toxicology
Glycoside
Hep G2 Cells
biology.organism_classification
Coumarin
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Chemistry (miscellaneous)
Hepg2 cells
Molecular Medicine
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.doi.dedup.....9471a96fb1b8e1740db95d5ea6dcf9d1