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Advances in Functional Imaging of Differentiated Thyroid Cancer

Advances in Functional Imaging of Differentiated Thyroid Cancer

Authors :
Livia Lamartina
Martin Schlumberger
Domenico Salvatore
Emanuele Nicolai
Elena Califaretti
Raffaele Ambrosio
Alberto Cuocolo
Carmela Nappi
Désirée Deandreis
Emilia Zampella
Michele Klain
Klain, Michele
Zampella, Emilia
Nappi, Carmela
Nicolai, Emanuele
Ambrosio, Raffaele
Califaretti, Elena
Lamartina, Livia
Schlumberger, Martin
Deandreis, Désirée
Salvatore, Domenico
Cuocolo, Alberto
Source :
Cancers, Cancers, Vol 13, Iss 4748, p 4748 (2021)
Publication Year :
2021
Publisher :
MDPI, 2021.

Abstract

Simple Summary Since the 1940s, radioactive iodine has been used for functional imaging and for treating patients with differentiated thyroid cancer (DTC). During this long-lasting experience, the use of iodine isotopes evolved, especially during the last years due to improved knowledge of thyroid cancer biology and improved performances of imaging tools. The present review summarizes recent advances in the field of functional imaging and theragnostic approach of DTC. Abstract The present review provides a description of recent advances in the field of functional imaging that takes advantage of the functional characteristics of thyroid neoplastic cells (such as radioiodine uptake and FDG uptake) and theragnostic approach of differentiated thyroid cancer (DTC). Physical and biological characteristics of available radiopharmaceuticals and their use with state-of-the-art technologies for diagnosis, treatment, and follow-up of DTC patients are depicted. Radioactive iodine is used mostly with a therapeutic intent, while PET/CT with 18F-FDG emerges as a useful tool in the diagnostic management and complements the use of radioactive iodine. Beyond 18F-FDG PET/CT, other tracers including 124I, 18F-TFB and 68Ga-PSMA, and new methods such as PET/MR, might offer new opportunities in selecting patients with DTC for specific imaging modalities or treatments.

Details

Language :
English
ISSN :
20726694
Volume :
13
Issue :
19
Database :
OpenAIRE
Journal :
Cancers
Accession number :
edsair.doi.dedup.....94784e359abec0a04c6e6c86c95b8137