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Cell-mediated Immunity to Human Tamm-Horsfall Glycoprotein in Autoimmune Liver Disease with Renal Tubular Acidosis
- Publication Year :
- 1974
-
Abstract
- Cell-mediated immune responses to Tamm-Horsfall glycoprotein isolated from human urine were investigated using the leucocyte migration test. Abnormal responses were found in 91% of patients with active chronic hepatitis or primary biliary cirrhosis with an associated renal tubular acidosis (R.T.A.) but in only 19% of those without R.T.A. In nearly all of a group of patients without autoimmune liver disease and in a control group of normal subjects results were within normal limits. In addition, using an immunofluorescent technique with rabbit antibody to human Tamm-Horsfall glycoprotein, it was possible to show the presence in human liver cell membrane of material reacting immunologically as Tamm-Horsfall. These findings suggest that the development of an immune response to this glycoprotein, initiated by release of cross-reacting antigens from damaged hepatocytes, could be the mechanism underlying the occurrence of R.T.A. in some patients with autoimmune liver disease.
- Subjects :
- Fluorescent Antibody Technique
Biology
Cross Reactions
Urine
Autoimmune Diseases
Hepatitis
Cell membrane
Renal tubular acidosis
Primary biliary cirrhosis
Immune system
Antigen
medicine
Leukocytes
Humans
General Environmental Science
Glycoproteins
chemistry.chemical_classification
Immunity, Cellular
Liver Cirrhosis, Biliary
Liver Diseases
Cell Membrane
General Engineering
Cell Migration Inhibition
General Medicine
Papers and Originals
Acidosis, Renal Tubular
Hydrogen-Ion Concentration
medicine.disease
medicine.anatomical_structure
chemistry
Liver
Immunology
General Earth and Planetary Sciences
Glycoprotein
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....947e9f44d7ae30b7d12725e5158ba489