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Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The aim of the study was the evaluation of the effectiveness of radiotherapy in elderly T1 glottic cancer patients and prognostic factors with particular focus on comorbidities. Five-year overall survival, disease-specific survival, and local control rates were 63%, 92%, and 93%, respectively. Multivariate analysis showed that the following factors had statistically significant impact on local relapse risk and cancer death risk: diabetes, underweight, and fraction dose of 2 Gy. High number of comorbidities, high CCI, and underweight negatively influenced overall survival. A retrospective analysis was performed in a group of 131 T1N0M0 glottic cancer patients aged 70 and above treated with irradiation at the National Institute of Oncology in Cracow between 1977 and 2007. In the analyzed group men prevailed (92%) of mean age of 74 years. Each patient was diagnosed with at least one comorbidity with the following comorbid conditions being most frequent: hypertension, ischemic heart disease, and chronic obstructive pulmonary disease. In the studied group, the effect of comorbidities on overall survival was evaluated using Charlson Comorbidity Index (CCI). Twenty five (19%) patients showed underweight. All patients were irradiated once daily, 5 days a week, to a total dose of 60–70 Gy with a fraction dose of 2 or 2.5 Gy. Radiotherapy is an effective treatment modality in elderly T1 glottic cancer patients. Diabetes as comorbidity, underweight, and conventional dose fractionation decrease the probability of curative effect of radiotherapy in this group of patients, while high number of comorbidities diminishes the probability of long-term survival.
- Subjects :
- Male
Glottis
medicine.medical_specialty
Multivariate analysis
Science
medicine.medical_treatment
Disease
Article
Internal medicine
Diabetes mellitus
medicine
Humans
Laryngeal Neoplasms
Cancer
Aged
Retrospective Studies
Aged, 80 and over
Multidisciplinary
business.industry
Body Weight
Dose fractionation
Radiotherapy Dosage
Prognosis
medicine.disease
Comorbidity
Survival Rate
Radiation therapy
Treatment Outcome
Oncology
Glottic cancer
Carcinoma, Squamous Cell
Medicine
Female
Dose Fractionation, Radiation
Underweight
medicine.symptom
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....947f44b6a2929c18722e29bec7d8baca