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Fracture Prevalence and Relationship to Endocrinopathy in Iron Overloaded Patients with Sickle Cell Disease and Thalassemia

Authors :
Robert Mignaca
Ellen B. Fung
Mark Ranalli
Charles D. Scher
Paul Harmatz
Alexis A. Thompson
Thomas D. Coates
Shanda Robertson
Patricia J. Giardina
Lynne Neumayr
Elliott Vichinsky
Meredith Milet
Publication Year :
2008

Abstract

Transfusional iron overload leads to gonadal failure and low bone mass in patients with thalassemia (Thal). However, gonadal failure is rarely reported in transfused patients with sickle cell disease (SCD) and the literature regarding fracture prevalence in SCD is limited. The objective of this study was to assess self-reported fracture prevalence and its relationship to endocrinopathy in transfused Thal or SCD subjects and compare to non-transfused subjects with SCD (NonTxSCD). Eligibility was based on age> or =12 years and liver iron concentration> or =10 mg/g dry wt or serum ferritin> or =2000 ng/mL (Thal or TxSCD) or for NonTxSCD, ferritin

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....94892b5d8ecbf02030d6f2303b98494f