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Mitochondrial Quality Control: Decommissioning Power Plants in Neurodegenerative Diseases
- Source :
- The Scientific World Journal, Vol 2013 (2013), The Scientific World Journal
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- The cell has an intricate quality control system to protect its mitochondria from oxidative stress. This surveillance system is multi-tiered and comprises molecules that are present inside the mitochondria, in the cytosol, and in other organelles like the nucleus and endoplasmic reticulum. These molecules cross talk with each other and protect the mitochondria from oxidative stress. Oxidative stress is a fundamental part of early disease pathogenesis of neurodegenerative diseases. These disorders also damage the cellular quality control machinery that protects the cell against oxidative stress. This exacerbates the oxidative damage and causes extensive neuronal cell death that is characteristic of neurodegeneration.
- Subjects :
- Programmed cell death
Mitochondrial Turnover
Cell
lcsh:Medicine
Review Article
Mitochondrion
Biology
medicine.disease_cause
lcsh:Technology
General Biochemistry, Genetics and Molecular Biology
Mitochondrial Proteins
medicine
Animals
Humans
lcsh:Science
General Environmental Science
lcsh:T
Endoplasmic reticulum
lcsh:R
Neurodegeneration
Ubiquitination
Neurodegenerative Diseases
General Medicine
medicine.disease
Mitochondria
Cell biology
Oxidative Stress
Cytosol
medicine.anatomical_structure
Proteolysis
lcsh:Q
Oxidative stress
Subjects
Details
- ISSN :
- 1537744X
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- The Scientific World Journal
- Accession number :
- edsair.doi.dedup.....948ac7b41b1df1de0216b4d16c233d1d