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Autologously generated tissue-engineered bone flaps for reconstruction of large mandibular defects in an ovine model
- Source :
- Tissue Engineering Part A, 21, 9-10, pp. 1520-8, Tissue Engineering Part A, 21, 1520-8
- Publication Year :
- 2015
-
Abstract
- Item does not contain fulltext The reconstruction of large craniofacial defects remains a significant clinical challenge. The complex geometry of facial bone and the lack of suitable donor tissue often hinders successful repair. One strategy to address both of these difficulties is the development of an in vivo bioreactor, where a tissue flap of suitable geometry can be orthotopically grown within the same patient requiring reconstruction. Our group has previously designed such an approach using tissue chambers filled with morcellized bone autograft as a scaffold to autologously generate tissue with a predefined geometry. However, this approach still required donor tissue for filling the tissue chamber. With the recent advances in biodegradable synthetic bone graft materials, it may be possible to minimize this donor tissue by replacing it with synthetic ceramic particles. In addition, these flaps have not previously been transferred to a mandibular defect. In this study, we demonstrate the feasibility of transferring an autologously generated tissue-engineered vascularized bone flap to a mandibular defect in an ovine model, using either morcellized autograft or synthetic bone graft as scaffold material. 01 mei 2015
- Subjects :
- medicine.medical_specialty
Scaffold
Facial bone
Materials science
X-ray microtomography
Biomedical Engineering
Bioengineering
Mandible
Biochemistry
Transplantation, Autologous
Surgical Flaps
Biomaterials
Prosthesis Implantation
Tissue engineering
medicine
Animals
Polymethyl Methacrylate
Craniofacial
Sheep
Tissue Engineering
Original Articles
X-Ray Microtomography
Plastic Surgery Procedures
Surgery
Transplantation
Disease Models, Animal
Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10]
Female
Biomedical engineering
Subjects
Details
- ISSN :
- 19373341
- Database :
- OpenAIRE
- Journal :
- Tissue Engineering Part A, 21, 9-10, pp. 1520-8, Tissue Engineering Part A, 21, 1520-8
- Accession number :
- edsair.doi.dedup.....94a5d739dd6687254693dd0f1c4a7b8c