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EGFR and KRAS mutation status in non-small-cell lung cancer occurring in HIV-infected patients
- Source :
- Lung Cancer, Lung Cancer, 2015, 96, pp.74-77. ⟨10.1016/j.lungcan.2015.11.021⟩, Lung Cancer, Elsevier, 2015, 96, pp.74-77. ⟨10.1016/j.lungcan.2015.11.021⟩
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- International audience; Non–small-cell lung cancer (NSCLC) is the most common non-acquired immune deficiency syndrome-related malignancy responsible for death. Mutational status is crucial for choosing treatment of advanced NSCLC, yet no data is available on the frequency of epidermal growth factor receptor (EGFR) and Kirsten ras (KRAS) mutations and their impact on NSCLC in human immunodeficiency virus (HIV)-infected patients (HIV-NSCLC).All consecutive HIV-NSCLC patients diagnosed between June 1996 and August 2013 at two Paris university hospitals were reviewed, with tumor samples analyzed for EGFR and KRAS mutational status.Overall, 63 tumor samples were analyzed out of 73HIV-NSCLC cases, with 63% of advanced NSCLC. There were 60 non-squamous and nine squamous cell carcinomas, with EGFR and KRAS mutations identified in two (3.3%) and seven (11.5%) tumors, respectively. The proportion of KRAS mutations was 29% if solely the more sensitive molecular techniques were considered. The two patients with advanced adenocarcinoma harboring EGFR mutations exhibited lasting partial response to EGFR-tyrosine kinase inhibitors. Overall survival for patients with advanced NSCLC were >30 months for those with EGFR mutations
- Subjects :
- Male
0301 basic medicine
Pulmonary and Respiratory Medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
DNA Mutational Analysis
non-small cell lung cancer (NSCLC)
[SDV.CAN]Life Sciences [q-bio]/Cancer
HIV Infections
medicine.disease_cause
Malignancy
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
0302 clinical medicine
Immune system
Carcinoma, Non-Small-Cell Lung
Internal medicine
medicine
Humans
Epidermal growth factor receptor
Lung cancer
neoplasms
Neoplasm Staging
biology
business.industry
Incidence
Hazard ratio
Middle Aged
Prognosis
medicine.disease
respiratory tract diseases
3. Good health
ErbB Receptors
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Cancer research
biology.protein
Adenocarcinoma
Female
KRAS
business
Subjects
Details
- ISSN :
- 01695002
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Lung Cancer
- Accession number :
- edsair.doi.dedup.....94c2697f1674b738cb8f86fd6d24acd9