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Nicotine-induced brain metabolism associated with anger provocation
- Source :
- Gehricke, Jean-G; Potkin, Steven G; Leslie, Frances M; Loughlin, Sandra E; Whalen, Carol K; Jamner, Larry D; et al.(2009). Nicotine-induced brain metabolism associated with anger provocation. Behavioral and Brain Functions, 5(1), 19. doi: 10.1186/1744-9081-5-19. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/09s2r9v0, Behavioral and Brain Functions, Vol 5, Iss 1, p 19 (2009), Behavioral and Brain Functions : BBF
- Publication Year :
- 2009
- Publisher :
- eScholarship, University of California, 2009.
-
Abstract
- Cortico-limbic brain activity associated with anger may be susceptible to nicotine and, thus, may contribute to smoking initiation and nicotine addiction. The purpose of the study was to identify the brain regions that are most reactive to nicotine and show the greatest association with anger task performance. Twenty adult nonsmokers (9 women, 11 men) participated in two laboratory sessions to assess brain metabolism with fluoro deoxy-glucose Positron Emission Topography (FDG-PET) in response to nicotine and placebo patches during an anger provocation task. Outcome variables for the anger provocation task were reaction time, intensity and length of retaliation. Reaction time was associated with nicotine-induced changes in the left thalamus. Length of retaliation was associated with a functionally linked set of cortical and subcortical structures such as right frontal lobe, right anterior cingulate (BA 24), right uncus, left parietal lobe, left BA 11, left cingulate, left BA 25, left amygdala, left BA 30, left BA 38 and BA 9. These findings reveal the underlying brain circuitry targeted by nicotine during anger provocation.
- Subjects :
- medicine.medical_specialty
Neurology
Brain activity and meditation
cerebral-blood-flow
Cognitive Neuroscience
Nicotine patch
medicine.medical_treatment
media_common.quotation_subject
Provocation test
memory storage
resting tobacco smokers
facial expressions
Anger
Social and Behavioral Sciences
behavioral disciplines and activities
lcsh:RC346-429
smoking
Nicotine
03 medical and health sciences
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Short Paper
functional mri
abstinence
Biological Psychiatry
lcsh:Neurology. Diseases of the nervous system
media_common
Life Sciences
General Medicine
human amygdala
neural systems
030227 psychiatry
Cerebral blood flow
chemistry
Cardiology
activation
Psychology
Cotinine
Neuroscience
030217 neurology & neurosurgery
psychological phenomena and processes
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Gehricke, Jean-G; Potkin, Steven G; Leslie, Frances M; Loughlin, Sandra E; Whalen, Carol K; Jamner, Larry D; et al.(2009). Nicotine-induced brain metabolism associated with anger provocation. Behavioral and Brain Functions, 5(1), 19. doi: 10.1186/1744-9081-5-19. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/09s2r9v0, Behavioral and Brain Functions, Vol 5, Iss 1, p 19 (2009), Behavioral and Brain Functions : BBF
- Accession number :
- edsair.doi.dedup.....94d1d312d714b4d94de5f0dddaba126b