Spheroplasts, poorly known but clinically relevant particles of urinary sediment

Background In two patients under treatment with various antibiotics, spheroplasts were detected with an automated urine sediment analyzer. Methods Urinalysis was performed by an AutionMAX AX 4030-sediMAX platform. Results Spheroplasts can be easily misclassified as yeasts or erythrocytes, but when automated urine sediment analyzers are used by well-trained, and experienced operators they can be correctly identified and classified. Conclusion Appropriate training of urine laboratory professionals in spheroplast detection and association with UTI, together with timely communication with the microbiologist and caring clinician, will provide prompt targeted treatment.