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A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12
- Source :
- Nature genetics. 45(8)
- Publication Year :
- 2013
-
Abstract
- To identify new genetic risk factors for cervical cancer, we conducted a genome-wide association study in the Han Chinese population. The initial discovery set included 1,364 individuals with cervical cancer (cases) and 3,028 female controls, and we selected a 'stringently matched samples' subset (829 cases and 990 controls) from the discovery set on the basis of principal component analysis; the follow-up stages included two independent sample sets (1,824 cases and 3,808 controls for follow-up 1 and 2,343 cases and 3,388 controls for follow-up 2). We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18). We additionally replicated an association between HLA-DPB1 and HLA-DPB2 (HLA-DPB1/2) at 6p21.32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). Our findings provide new insights into the genetic etiology of cervical cancer.
- Subjects :
- Adult
Han chinese
China
Uterine Cervical Neoplasms
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Asian People
Genetics
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
Cervical cancer
fungi
Computational Biology
Reproducibility of Results
Middle Aged
medicine.disease
Genetic Loci
Case-Control Studies
Susceptibility locus
Female
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 17
Follow-Up Studies
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15461718
- Volume :
- 45
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....94fa584708788db3fe89a77fa342976e