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Vascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectives
- Source :
- Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos), Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação, instacron:RCAAP
- Publication Year :
- 2017
-
Abstract
- Vision loss due to disease or degeneration of the eye (retina, choroid, retinal veins, or macula) is a leading cause of blindness worldwide. In most cases, vision-threatening ocular diseases are accompanied by abnormal changes in the vasculature of the eye, especially the retina, and these conditions are collectively referred to as retinal vasculopathies. Impaired blood supply or hypoxia stimulates angiogenesis in the vascular and non-vascular sections of the eye, which results in neovascularization, leading to conditions such as diabetic retinopathy or age-related macular degeneration. Studies show that vascular endothelial growth factors: VEGF-A, VEGF-B, and placental growth factor (PlGF) are elevated in these diseases, and hence, these factors could be used as markers for disease prognosis and therapy. In this review, we discuss the function of these growth factors in normal development and disease, with focus on ocular disorders and emphasize the importance of accurately determining their levels in the vitreous and serum of patients for correct diagnosis and therapy.
- Subjects :
- 0301 basic medicine
Placental growth factor
medicine.medical_specialty
genetic structures
Angiogenesis
Endocrinology, Diabetes and Metabolism
Immunology
Ophthalmic disorders
General Biochemistry, Genetics and Molecular Biology
Neovascularization
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
Retinal Diseases
Ophthalmology
medicine
Immunology and Allergy
Animals
Humans
Vascular Diseases
Hypoxia
Placental growth factor (PIGF)
Placenta Growth Factor
Retina
Neovascularization, Pathologic
business.industry
Vascular Endothelial Growth Factors
Retinal
Diabetic retinopathy
Macular degeneration
medicine.disease
Prognosis
eye diseases
Vitreous Body
030104 developmental biology
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
sense organs
Choroid
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 18790305
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Cytokinegrowth factor reviews
- Accession number :
- edsair.doi.dedup.....950583a29f099a2d75cb1ce57260535a