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Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia

Authors :
Xue Xiang
Xin Wang
Cheng-Cheng Ma
Ying Gao
Wan Li Hu
Huiling Chen
Ye Chai
Source :
Journal of International Medical Research, Vol 48 (2020), The Journal of International Medical Research
Publication Year :
2020
Publisher :
SAGE Publishing, 2020.

Abstract

Blast crisis develops in a minority of patients with chronic myeloid leukemia even in the era of tyrosine kinase inhibitor (TKI) therapy. Reports suggest that we know little about the mechanism of BCR-ABL and AML1-ETO co-expression in blast crisis of chronic myeloid leukemia, and that other chromosomal abnormalities also coexist. Here, we document an unusual and interesting case of a 51-year-old female diagnosed in the chronic phase of chronic myeloid leukemia. After undergoing TKI treatment for 3 months, her bone marrow aspirates in the chronic phase had transformed to blast crisis. Molecular genetic testing indicated she was positive for p210 form of BCR-ABL (copy number decreased from 108.91% to 56.96%) and AML1-ETO fusion (copy number, 5.65%) genes and had additional chromosomal abnormalities of t(8; 21)(q22; q22)/t(9; 22)(q34; q11), t(2; 5)(p24; q13) and an additional +8 chromosome.

Details

Language :
English
ISSN :
14732300
Volume :
48
Database :
OpenAIRE
Journal :
Journal of International Medical Research
Accession number :
edsair.doi.dedup.....9523c5e817cf6492ee12c69247c76e67