Back to Search
Start Over
Clonal evolution of AML1-ETO coexisting with BCR-ABL and additional chromosome abnormalities in a blastic transformation of chronic myeloid leukemia
- Source :
- Journal of International Medical Research, Vol 48 (2020), The Journal of International Medical Research
- Publication Year :
- 2020
- Publisher :
- SAGE Publishing, 2020.
-
Abstract
- Blast crisis develops in a minority of patients with chronic myeloid leukemia even in the era of tyrosine kinase inhibitor (TKI) therapy. Reports suggest that we know little about the mechanism of BCR-ABL and AML1-ETO co-expression in blast crisis of chronic myeloid leukemia, and that other chromosomal abnormalities also coexist. Here, we document an unusual and interesting case of a 51-year-old female diagnosed in the chronic phase of chronic myeloid leukemia. After undergoing TKI treatment for 3 months, her bone marrow aspirates in the chronic phase had transformed to blast crisis. Molecular genetic testing indicated she was positive for p210 form of BCR-ABL (copy number decreased from 108.91% to 56.96%) and AML1-ETO fusion (copy number, 5.65%) genes and had additional chromosomal abnormalities of t(8; 21)(q22; q22)/t(9; 22)(q34; q11), t(2; 5)(p24; q13) and an additional +8 chromosome.
- Subjects :
- Medicine (General)
Oncogene Proteins, Fusion
medicine.drug_class
Fusion Proteins, bcr-abl
Abnormal Karyotype
Case Report
Biochemistry
Somatic evolution in cancer
Translocation, Genetic
Tyrosine-kinase inhibitor
03 medical and health sciences
RUNX1 Translocation Partner 1 Protein
0302 clinical medicine
R5-920
chronic myeloid leukemia
Bone Marrow
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
hemic and lymphatic diseases
medicine
AML1-ETO
Humans
BCR-ABL
Gene
Chromosome Aberrations
Clonal evolution
business.industry
Biochemistry (medical)
additional chromosome
Myeloid leukemia
Chromosome
Cell Biology
General Medicine
Middle Aged
blast crisis
Aml1 eto
Transformation (genetics)
medicine.anatomical_structure
Karyotyping
030220 oncology & carcinogenesis
Core Binding Factor Alpha 2 Subunit
Cancer research
Female
Bone marrow
business
Biomarkers
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 14732300
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Journal of International Medical Research
- Accession number :
- edsair.doi.dedup.....9523c5e817cf6492ee12c69247c76e67