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Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation

Authors :
Ignacia Braga Tanaka
Chihiro Harada
Yoshiko Ayabe
Jun-ichiro Komura
Keiji Ogura
Satoshi Tanaka
Source :
International Journal of Molecular Sciences, Vol 22, Iss 12437, p 12437 (2021), International Journal of Molecular Sciences, Volume 22, Issue 22
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

There is very little information on the transgenerational or genetic effects of low dose-rate ionizing radiation. We report the detection of the transgenerational effects of chronic low dose-rate irradiation in mice, at the molecular level in the whole genome, using array comparative genomic hybridization technology. We observed that the number of the mice with de novo copy number variations (specifically, deletions) was significantly increased in the offspring of C57BL/6J male mice exposed to 20 mGy/day gamma-rays for 400 days (total dose: 8000 mGy), as compared to non-irradiated controls. We did not detect any difference in the size of the de novo deletions between the irradiated and the non-irradiated groups. An analysis of the life span of the offspring suggested a possibility that de novo copy-number variations may be associated with shorter life spans.

Details

Language :
English
ISSN :
16616596 and 14220067
Volume :
22
Issue :
12437
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....95398ad62cfd132130be74cf753a4442