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Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation
- Source :
- International Journal of Molecular Sciences, Vol 22, Iss 12437, p 12437 (2021), International Journal of Molecular Sciences, Volume 22, Issue 22
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- There is very little information on the transgenerational or genetic effects of low dose-rate ionizing radiation. We report the detection of the transgenerational effects of chronic low dose-rate irradiation in mice, at the molecular level in the whole genome, using array comparative genomic hybridization technology. We observed that the number of the mice with de novo copy number variations (specifically, deletions) was significantly increased in the offspring of C57BL/6J male mice exposed to 20 mGy/day gamma-rays for 400 days (total dose: 8000 mGy), as compared to non-irradiated controls. We did not detect any difference in the size of the de novo deletions between the irradiated and the non-irradiated groups. An analysis of the life span of the offspring suggested a possibility that de novo copy-number variations may be associated with shorter life spans.
- Subjects :
- Male
DNA Copy Number Variations
Offspring
QH301-705.5
Longevity
low dose-rate
Male mice
Biology
Radiation Dosage
Genome
Article
Catalysis
Ionizing radiation
Inorganic Chemistry
Andrology
Mice
Pregnancy
Animals
Low dose rate
Copy-number variation
Irradiation
Physical and Theoretical Chemistry
Biology (General)
Molecular Biology
QD1-999
Spectroscopy
Comparative Genomic Hybridization
transgenerational effects
Organic Chemistry
array comprehensive genomic hybridization (array CGH)
General Medicine
Computer Science Applications
Mice, Inbred C57BL
Chemistry
copy number variation (CNV)
Gamma Rays
Prenatal Exposure Delayed Effects
Paternal Exposure
Female
genetic effects
ionizing radiation
Comparative genomic hybridization
Subjects
Details
- Language :
- English
- ISSN :
- 16616596 and 14220067
- Volume :
- 22
- Issue :
- 12437
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....95398ad62cfd132130be74cf753a4442