Back to Search Start Over

A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

Authors :
Jan Hubeňák
Stefan Kaiser
Armida Mucci
W. Wolfgang Fleischhacker
Gabriele Sachs
Andreas Erfurth
Sonia Dollfus
Jan Libiger
Ingrid Melle
Stephen F. Austin
Paweł Wójciak
Karoline Gütter
István Bitter
Birte Glenthøj
Alp Üçok
A. Vignapiano
Mette Ødegaard Nielsen
Oleg Papsuev
Alex Hofer
Camille Delouche
Igor Gladyshev
Giulia Maria Giordano
Silvana Galderisi
Janusz K. Rybakowski
Mucci, A.
Vignapiano, A.
Bitter, I.
Austin, S. F.
Delouche, C.
Dollfus, S.
Erfurth, A.
Fleischhacker, W. W.
Giordano, G. M.
Gladyshev, I.
Glenthoj, B.
Gutter, K.
Hofer, A.
Hubenak, J.
Kaiser, S.
Libiger, J.
Melle, I.
Nielsen, M. O.
Papsuev, O.
Rybakowski, J. K.
Sachs, G.
Ucok, A.
Wojciak, P.
Galderisi, S.
Source :
Mucci, A, Vignapiano, A, Bitter, I, Austin, S F, Delouche, C, Dollfus, S, Erfurth, A, Fleischhacker, W W, Giordano, G M, Gladyshev, I, Glenthøj, B, Gütter, K, Hofer, A, Hubeňák, J, Kaiser, S, Libiger, J, Melle, I, Nielsen, M Ø, Papsuev, O, Rybakowski, J K, Sachs, G, Üçok, A, Wojciak, P & Galderisi, S 2019, ' A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale ', European Neuropsychopharmacology, vol. 29, no. 8, pp. 947-959 . https://doi.org/10.1016/j.euroneuro.2019.05.006, European Neuropsychopharmacology, Vol. 29, No 8 (2019) pp. 947-959
Publication Year :
2019

Abstract

Negative symptoms represent an unmet need of treatment in schizophrenia. Although a consensus exists on negative symptom construct, and second generation assessment instruments reflecting the consensus are available, studies still rely upon old assessment instruments, that do not reflect recent conceptualizations and might limit progress in the search for effective treatments. This is often the case in the European context, where one of the challenges encountered in designing large studies is the availability of validated instruments in the many languages of the continent. To address this challenge and promote sound research on negative symptoms in Europe, the ECNP Schizophrenia Network coordinated a large multicenter, multinational validation study of the Brief Negative Symptom Scale (BNSS). Clinically-stable subjects with schizophrenia (SCZ, N = 249) were recruited from 10 European Countries. Apart from BNSS, subjects were administered the Positive and Negative Syndrome Scale (PANSS) and standardized instruments for depression, extrapyramidal symptoms and psychosocial functioning. Results showed an excellent internal consistency, convergent and discriminant validity of BNSS and replicated a 5 factor-model. A larger number of subjects with predominant negative symptoms, i.e. the target population for clinical trials, was identified by using the BNSS compared to the PANSS. Regression analysis showed that BNSS-avolition, a key negative symptom poorly assessed by PANSS, explained 23.9% of psychosocial functioning, while no combination of the PANSS core negative symptoms showed the same impact on functioning. The study demonstrated that BNSS has substantial advantages with respect to PANSS for the identification of the avolition domain and subjects with predominant negative symptoms. (C) 2019 The Author(s). Published by Elsevier B.V.

Details

ISSN :
18737862 and 0924977X
Volume :
29
Issue :
8
Database :
OpenAIRE
Journal :
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Accession number :
edsair.doi.dedup.....9541ee1f224aeff1afcf6d32beae72f8