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Efficacy of alprostadil for preventing of contrast-induced nephropathy: A meta-analysis
- Source :
- Scientific Reports, Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
- Publication Year :
- 2017
- Publisher :
- Nature Publishing Group UK, 2017.
-
Abstract
- Contrast-induced nephropathy (CIN) has become the third-leading cause of hospital-acquired acute renal injury. Although alprostadil has been proposed as an effective preventative measure, this conclusion remains inconsistent. Thus, we performed a meta-analysis of the published studies on this topic to evaluate the preventative effect of alprostadil on CIN. Databases, including PubMed, the Web of Science, Cochrane Library, Wanfang, the China Biological Medicine Database (SinoMed) and the China National Knowledge Infrastructure (CNKI) were systematically searched. Nineteen clinical trials involving 2267 individuals were identified. We utilized a random or a fixed effect model to calculate the pooled odd ratios (ORs) and the standardized mean differences (SMD), respectively. Compared to the control group, the CIN risk decreased significantly in the alprostadil group (P
- Subjects :
- medicine.medical_specialty
Multidisciplinary
business.industry
Incidence (epidemiology)
Science
030232 urology & nephrology
Contrast-induced nephropathy
Acute kidney injury
030204 cardiovascular system & hematology
Cochrane Library
medicine.disease
Article
Nephropathy
Clinical trial
03 medical and health sciences
0302 clinical medicine
Meta-analysis
Internal medicine
medicine
Medicine
business
Risk assessment
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....954e2306185dae254398226250fed1d6
- Full Text :
- https://doi.org/10.1038/s41598-017-01160-1