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Old fusidane-type antibiotics for new challenges: Chemistry and biology
- Source :
- Chinese Journal of Natural Medicines. 20:81-101
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections untreatable now and in the future. To deal with these "new challenges", scientists tend to re-pick up "old antibiotics". Fusidane-type antibiotics have been known for nearly 80 years as potent antibacterial agents against gram-positive bacteria, especially Staphylococci, and represent the only triterpene-derived antibiotic class in clinical setting. These attractive characteristics have drawn renewed attention on fusidane-type antibiotics in recent decades. Isolation, characterization, biological evaluation, as well as chemical modifications of fusidane-type antibiotics are increasingly being reported. Combinatorial biosynthesis of this type of antibiotics has been successfully utilized not only for elucidating the biosynthetic pathways, but also for expanding their structural diversity. Some isolated and synthetic compounds exhibit comparable or even more potent biological activity than fusidic acid. This review provides an overview of progress on the studies of structure and biology of fusidane-type antibiotics from 1943 to April 2021. The informative structure-activity relationship is also highlighted.
- Subjects :
- Bacteria
medicine.drug_class
Fusidic acid
Antibiotics
Structural diversity
General Medicine
Computational biology
Biology
biology.organism_classification
Anti-Bacterial Agents
Structure-Activity Relationship
Complementary and alternative medicine
Combinatorial biosynthesis
Drug Discovery
medicine
Biological evaluation
medicine.drug
Subjects
Details
- ISSN :
- 18755364
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Natural Medicines
- Accession number :
- edsair.doi.dedup.....954fefc1f05b353af8b2d2f04757b8bc